Over 25 years ago, a pharmaceutical company outside of the U.S. created a line of topical formulas containing Minoxidil, Tretinoin (a topical steroid that reduces irritation and inflammation associated with topical Minoxidil use), and Oleanolic Acid (a 5-alpha reductase inhibitor). The group also developed a novel method for solubilizing and stabilizing Minoxidil that allowed for greater stability, longer shelf life, and better efficacy versus previously available Minoxidil formulations.

In 2008, a group of leading dermatologists in Mexico, including Dr. Antonio Cueva, introduced these formulas to market in Mexico, under the label Saude. The group performed a series of clinical trials that showed a markedly faster onset and more profound hair growth than had been seen with previous Minoxidil-based formulas by the majority of patients involved in their trials.

In 2009, Hair Science was established in the U.S. to further advance the products developed by the Saude group, with the assistance of cosmetic dermatologist and aesthetic surgeon, Dr. Mark Rubin in Beverly Hills, CA and the MasterPharm Compounding Pharmacy in New York. The latest version of the formulation, Formula 82M, is now offered by prescription in the US under license from Hair Science.

In 2014, following the success of 82m, Hair Science launched an over-the-counter hair loss shampoo, Formula 82S, containing the botanically derived 5-α reductase inhibitor, Serenoa Repens (Saw Palmetto), featuring an array of natural conditioners and amino acids shown in scientific studies to strengthen hair and restore natural texture. Formula 82S Hair Loss Shampoo is currently available through Hair Science-partnered medical spas, hair restoration clinics, doctor offices, and select salons throughout North America, and can be purchased on Amazon by consumers.

In 2016, Hair Science further advanced the Formula 82M formulation to include topical Finasteride, leading to the creation of Formula 82F, now being offered by prescription in the US under license from Hair Science.

In 2019, Hair Science joined with Pure Integrative Pharmacy in Canada to offer its advanced hair loss formulas, Formulas 82M, 82F, 82D, to patients in Canada. While Replete Nutraceutical Labs holds the distribution rights for Formula 82S in Canada at this time.

In 2020, AnazaoHealth began compounding the latest versions of Formulas 82M & 82F for patients in the US.

In 2021, Hair Science further advanced the Formula 82M formulation to include topical Dutasteride, leading to the creation of Formula 82D.

In 2023, Carie Boyd Pharmaceuticals began compounding the latest versions of Formula 82M, 82F, & 82D under exclusive license from Hair Science in the US.